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2025

A non-hydrolysable peptidomimetic for mitochondrial targeting

Folgar-Cameán, Y.; Torralba-Maldonado, D.; Fulias-Guzmán, P.; Pazo, M.; Máximo-Moreno, I.; Royo, M.; Illa, O.; Montenegro, J.

J. Mater. Chem. B,2025, Advance Article (https://doi.org/10.1039/D4TB01626B)

A bioinspired and environmentally sustainable polyphenol-based water adhesive

López-Moral, A.; Bolaños-Cardet, J.; Alibés, R.; Busqué, F.; Yuste, V. J.; Ruiz-Molina, D.; Suárez-García, S.

J. Colloid Interface Sci. 2025, 680, 987 (https://doi.org/10.1016/j.jcis.2024.11.042)

2024

Tuning the Properties of Rigidified Acyclic DEDPA2– Derivatives for Application in PET Using Copper-64

Torralba-Maldonado, D.; Marlin, A.; Lucio-Martínez, F.; Freire-García, A.; Whetter, J.; Brandariz, I.; Iglesias, E.; Pérez-Lourido, P.; Ortuño, R. M.; Boros, E.; Illa, O.; Esteban-Gómez, D.; Platas-Iglesias, C.

Inorg. Chem. 2024, 63, 22297 (https://doi.org/10.1021/acs.inorgchem.4c04050)

Mussel-Inspired Multifunctional Polyethylene Glycol Nanoparticle Interfaces

Casagualda , C.; López-Moral, A.; Alfonso-Triguero, P.; Lorenzo, J.; Alibés, R.; Busqué, F.; Ruiz-Molina, D.

Biomimetics 2024, 9, 531(https://doi.org/10.3390/biomimetics9090531)

Chiral Cyclobutane-Based Ureas as Versatile Platforms to Tune Structural Diversity: An Experimental and Theoretical Approach

Illa, O.; Da Silva, E.; Torres, E.; Álvarez-Larena, Á.; Wurst, K.; Ortuño, R. M.; Branchadell, V.

Cryst. Growth Des. 2024, 24, 2807 (https://doi.org/10.1021/acs.cgd.3c01467)

2023

PITB: A high affinity transthyretin aggregation inhibitor with optimal pharmacokinetic properties

Pinheiro, F.; Varejão; N.; Sánchez-Morales, A.; Bezerra, F.; Navarro, S.; Velázquez-Campoy, A.; Busqué, F.; Almeida, M.R.; Alibés, R.; Reverter, D.; Pallarès, I.; Ventura, S.

Eur. J. Med. Chem. 2023, 261, 115837 (https://doi.org/10.1016/j.ejmech.2023.115837).

Mussel-Inspired Lego Approach for Controlling the Wettability of Surfaces with Colorless Coatings

Casagualda, C.; Mancebo-Aracil, J.; Moreno-Villaécija, M.; López-Moral, A.; Alibés, R.; Busqué, F.; Ruiz-Molina, D.

Biomimetics 2023, 8, 3 (https://doi.org/10.3390/biomimetics8010003)

2022

Development of a Highly Potent Transthyretin Amyloidogenesis Inhibitor: Design, Synthesis, and Evaluation

Pinheiro, F.; Pallarès, I.; Peccati, F.; Sánchez-Morales, A.; Varejão, N.; Bezerra, F.; Ortega-Alarcon, D.; Gonzalez, D.; Osorio, M.; Navarro, S.; Velázquez-Campoy, A.; Almeida, M.-R.; Reverter, D.; Busqué, F.; Alibés, R.; Sodupe, M.; Ventura, S.

J. Med. Chem. 2022, 65, 21, 14673-14691 (https://doi.org/10.1021/acs.jmedchem.2c01195).

Conformationally Locked Carbocyclic Nucleosides Built on a 4′-Hydroxymethyl-3′-hydroxybicyclo[4.1.0]heptane Template. Stereoselective Synthesis and Antiviral Activity

Jurado, S.; Illa, O.; Álvarez-Larena, A.; Pannecouque, C.; Busqué, F.; Alibés, R.

J. Org. Chem. 2022, 87, 22, 15166-15177 (https://doi.org/10.1021/acs.joc.2c01661).

Reduction of stress responses in honey bees by synthetic ligands targeting an allatostatin receptor

Sánchez-Morales, A.; Gigoux, V.; Matsoukas, M.-T.; Perez-Benito, L.; Fourmy, D.; Alibés, R.; Busqué, F.; Cordomi, A.; Devaud, J.-M.

Sci. Rep. 2022, 12, 16760 (https://doi.org/10.1038/S41598-022-20978-Y).

Enantiocontrolled Preparation of ϒ-Substituted Cyclohexenones: Synthesis and Kinase Activity Assays of Cyclopropyl-Fused Cyclohexane Nucleosides

Jurado, S.; Domínguez-Pérez, B.; Illa, O.; Balzarini, J.; Busqué, F.; Alibés, R.

Int. J. Mol. Sci. 2022, 23, 9704 (https://doi.org/10.3390/ijms23179704).

Design and synthesis of a novel non peptide CN-NFATc signaling inhibitor for tumor suppression in triple negative breast cancer

Sánchez-Morales, A., Biçer, A.; Panagiotopoulos, V.; Crecente-Garciaa, S.; Benaiges, C.; Bayod, S.; Hernández, J.L.; Busqué, F.; Matsoukas, M.-T.; Pérez-Riba, M.; Alibés, R.

Eur. J. Med. Chem. 2022, 238, 114514 (https://doi.org/10.1002/anie.202111228).

Clip-off Chemistry: Synthesis by Programmed Disassembly of Reticular Materials

Yang, Y.H.; Broto-Ribas, A.; Ortín-Rubio, B.; Imaz, I.; Gandara, F.; Carné-Sánchez, A.; Guillerm, V.; Jurado, S.; Busqué, F.; Juanhuix, J.; Maspoch, D.

Angew. Chem. Int. Ed. 2022, 61, e202111228 (https://doi.org/10.1002/anie.202111228).

2021

Design of negative and positive allosteric modulators of the cannabinoid CB2 receptor derived from the natural product cannabidiol

Navarro, G.; Gonzalez, A.; Sánchez-Morales, A; Casajuana-Martin, N.; Gómez-Ventura, M.; Cordomí, A.; Busqué, F.; Alibés, R.; Pardo, L.; Franco, R.

J. Med. Chem. 2021, 64, 9354-9364. (https://doi.org/10.1021/acs.jmedchem.1c00561)

Antitumour activity of coordination polymer nanoparticles

Suárez-García, S; Solórzano, R.; Alibés, R.; Busqué, F.; Novio, F.; Ruiz-Molina, D.

Coord. Chem. Rev. 2021, 441, 213977 (https://doi.org/10.1016/j.ccr.2021.213977).

Coordination polymers nanoparticles for bioimaging

Suárez-García, S; Solórzano, R.; Novio, F.; Alibés, R.; Busqué, F.; Ruiz-Molina, D.

Coord. Chem. Rev. 2021, 432, 213716 (https://doi.org/10.1016/j.ccr.2020.213716).

Nanoscale coordination polymers for medicine and sensors

Solórzano, R.; Suárez-García, S; Novio, F.; Lorenzo, J.; Alibés, R.; Busqué, F.; Ruiz-Molina, D.

Adv. Inorg. Chem. 2020, 76, 3-31 (https://doi.org/10.1016/bs.adioch.2020.03.001).

Bioinspired Functional Catechol Derivatives Through Simple Thiol Conjugate Addition

Mancebo-Aracil J.; Casagualda, C.; Moreno-Villaécija, M. A.; Gabriela Nador, F. G.; García-Pardo, J.; Franconetti-García, A.; Busqué, F.; Alibés, R.; Ruiz-Molina, D.; Sedó-Vegara, J.

Chem. Eur. J. 2019, 25, 12367-12379 (https://doi.org/10.1002/chem.201901914)

Synthetic photoswitchable neurotransmitters based on bridged azobenzenes

Cabre, G.; Garrido-Charles, A.; González_Lafont, A.; Moormann, W.; Langbehn, D.; Egea, D.; Lluch, J.-M.; Herges, R.; Alibes, R.; Busque, F.; Gorostiza, P.; Hernando, J

Org. Lett. 2019, 21, 3780-3784 (https://doi.org/10.1021/acs.orglett.9b01222).

Rationally designed azobenzene photoswitches for efficient two-photon neuronal excitation

Cabre, G.; Garrido-Charles, A.; Moreno, M.; Bosch, M.; Porta-de-la-Riva, M.; Krieg, M.; Gascon-Moya, M.; Camarero, N.; Gelabert, R.; Lluch, J.-M.; Busque, F.; Hernando, J.; Gorostiza, P.; Alibes, R.

Nat. Commun. 2019, 83, 907 (https://doi.org/10.1038/s41467-019-08796-9)

Versatile Iron-Catechol based Nanoscale Coordination Polymers Antiretroviral Ligand Functionalization and their use as Efficient Carriers in HIV/AIDS Therapy

Solórzano, R.; Tort, O.; García-Pardo, J.; Escribà, T.; Lorenzo, J.; Arnedo, M.; Ruiz-Molina, D.; Alibés, R.; Busqué, F.; Novio, F.

Biomater. Sci. 2019, 7, 178-186 (https://doi.org/10.1039/c8bm01221k)

The Chemistry behind Catechol-Based Adhesion

Saiz-Poseu, J.; Mancebo-Aracil, J.; Nador, F.; Busqué, F.; Ruiz-Molina, D.

Angew. Chem. Int. Ed. 2019, 58, 696-714. (https://doi.org/10.1002/anie.201801063)

Intramolecular photocycloaddition of 2(5H)‑furanones to temporarily tethered terminal alkenes as a stereoselective source of enantiomerically pure polyfunctionalyzed cyclobutanes

Xin, Y.; Rodríguez-Santiago, L.; Sodupe, M.; Álvarez-Larena, A.; Busqué, F.; Alibés, R.

J. Org. Chem. 2018, 83, 3188-3199 (https://doi.org/10.1021/acs.joc.8b00088)

Carbon nanotube-based nanocomposite sensor tuned with a catechol as novel electrochemical platform of uranyl ion in aqueous samples.

Munoz, J.; Montes, R.; Bastos-Arrieta, J.; Guardingo, M.; Busqué, F.; Ruiz-Molina, D.; Palet, C.;García-Orellana, J.; Baeza, M.

Sens. Actuators B Chem. 2018, 273, 1807-1815 ( https://doi.org/10.1016/j.snb.2018.07.093)

Replacing Nitrogen by Sulfur: from Structurally Disordered Eumelanins to regioregular Thiomelanin.

Iacomino, M.; Mancebo-Aracil, J.; Guardingo, M.; Martín, R.; D’Errico, G.; Perfetti, M.; Manini, P.; Crescenzi, O.; Busqué, F.; Napolitano, A.; d’Ischia, M.; Sedó, J.; Ruíz-Molina, D.

Int. J. Mol. Sci. 2017, 18, 2169 (https://doi.org/10.3390/ijms18102169).

pH Responsive Relaxometric Behaviour of Coordination Polymer Nanoparticles made of a Stable Macrocyclic Gadolinium Chelate

Arinez-Soriano, J.; Albalad, J.; Carné-Sánchez, A.; Bonet, C.S.; Busqué, F.; Lorenzo, J.; Juanhuix, J.; Terban, M.W.; Imaz, I.; Toth, E.; Maspoch, D.

Chem. Eur. J. 2016, 22, 13162-13170 (https://doi.org/10.1002/chem.201602356).

Synthesis of Nanoscale Coordination Polymers in Femtoliter Reactors on Surfaces

Guardingo, M.; González-Monje, P.; Novio, F.; Bellido, E.; Busqué, F.; Molnar, G.; Bousseksou, A.; Ruiz-Molina, D.

ACS Nano 2016, 10, 3206-3213 (https://doi.org/10.1021/acsnano.5b05071).

Biocompatible polydopamine-like particles for the removal of heavy metals at extremely low concentrations

Rodriguez, A. R. C.; Saiz-Poseu, J.; García-Pardo, J.; García, B.; Lorenzo, J.; Ojea-Jimenez, I.; Komlis, D.; Sedó, J.; Busqué, F.; Sánchez, A.; Ruiz-Molina, D.; Font, X.

RSC Adv. 2016, 6, 40058-40066 (https://doi.org/10.1039/C6RA03664C).

Two step synthesis of heterometallic coordination polymers using a polyazamacrocyclic linker

Arinez-Soriano, J.; Albalad, J.; Perez-Carbajal, J.; Imaz, I.; Busqué, F.; Juanhuix, J.; Maspoch, D.

CrysEngComm. 2016, 18, 4196-4204 (https://doi.org/10.1021/acs.inorgchem.5b00598).

Filling some blanks in a divergent approach to gabosines: enantioselective synthesis of (-)-Epiepoxydon, (+)-Phyllostine, (-)-Gabosine D, and (-)-Gabosine E

Fresneda, M. A.; Alibés, R.; Bayón, P.; Figueredo, M.

Eur. J. Org. Chem. 2016, 3568-3564 (https://doi.org/10.1002/ejoc.201600492).

Synthetic studies on stemona alkaloids. construction of the sessilifoliamides B and C and 1,12-secostenine skeleton

Alonso-Fernández, J.; Benaiges, C.; Casas, E.; Alibés, R.; Bayón, P.; Busqué, F.: Álvarez-Larena, A.; Figueredo, M.

Tetrahedron 2016, 22, 3500-3524 (https://doi.org/10.1016/j.tet.2016.04.077)

A Study on the photoreaction of 2(5H)-furanones with substituted acetylenes: Evidence for a mechanistic reformulation.

Flores, R.; Font, J.; Alibés, R.; Figueredo, M.

Chem. Eur. J. 2016, 22, 3835-3845. (https://doi.org/10.1002/chem.201503888)

Special Issue: Women in Chemistry

Intramolecular photoreactions of (5S)-5-oxymethyl-2(5H)-furanones as a tool for the stereoselective generation of diverse polycyclic scaffolds

Lejeune, G.; Font, J.; Parella, T.; Alibés, R.; Figueredo, M.

J. Org. Chem. 2015, 80, 9437-9455 (https://doi.org/10.1021/acs.joc.5b01354).

Synthesis of novel nucleoside analogues built on a bicyclo[4.1.0]heptane scaffold

Domínguez-Pérez, B.; Ferrer, E.; Figueredo, E.; Maréchal, J.-D.; Balzarini, J.; Alibés, R.; Busqué, F.

J. Org. Chem. 2015, 80, 9495-9505 (https://doi.org/10.1021/acs.joc.5b01413)

An optimized glutamate receptor photoswitch with sensitized azobenzene isomerization

Gascón-Moya, M.; Pejoan, A.; Izquierdo-Serra, M.; Pittolo, S.; Gisela Cabré, G.; Hernando, J.; Alibés, R.; Gorostiza, P.; Busqué, F.

J. Org. Chem. 2015, 80, 9915-9925 (https://doi.org/10.1021/acs.joc.5b01402)

Diastereoselectivity studies on the photo-activated cycloaddition of 5-(1,2-dioxyethyl)-2(5H)-furanones to alkenes

Cucarull-González, J.R.; Alibés, R.; Figueredo, M.; Font, J.

Arkivoc 2015, 193-213 (https://doi.org/10.3998/ark.5550190.0016.314)

Issue in Honor of Prof. Michael Orfanopoulos

Design and Synthesis of a Noninnocent Multitopic Catechol and Pyridine mixed ligand: Nanoscale Polymers and Valence Tautomerism.

Guardingo, M.; Busqué, F.; Novio, F.; Ruiz-Molina D.

Inorg. Chem. 2015, 54, 6776-6781 (https://doi.org/10.1021/acs.inorgchem.5b00598).

Mussel-inspired hydrophobic coatings for water-repellent textiles and oil removal

García, B.; Saiz-Poseu, J.; Gras-Charles, R.; Hernando, J.; Alibés, R.; Novio, F.; Sedó, J.; Busqué, F.; Ruiz-Molina, D.

ACS Appl. Mater. 2014, 17616-17625 (https://doi.org/10.1021/am503733d)

Two-photon neuronal and astrocytic stimulation with azobenzene-based photoswitches

Izquierdo-Serra, M.; Gascón-Moya, M.; Hirtz, J. J.; Pittolo, S.; Poskanzer, K. E.; Ferrer, E.; Alibés, R.; Busqué, F.; Yuste, R.; Hernando, J.; Gorostiza, P.

J. Am. Chem. Soc. 2014, 136, 8693-8701 (https://doi.org/10.1021/ja5026326).

Bioinspired catecholterminated self-assembled monolayers with enhanced adhesion properties

Guardingo, M.; Bellido, E.; Miralles,-Llumà, F.; Faraudo, J.; Verdaguer, A.; Sedó, J.; Tatay, S.; Busqué, F.; Ruiz-Molina, D.

Small 2014, 10, 1594-1602 (https://doi.org/10.1002/smll.201302406).

Stereodivergent synthesis of (+)- and (-)-isolineatin

Pérez, L.; Alibés, R.; de March, P.; Busqué, F.; Figueredo, M.; Font, J.

J. Org. Chem. 2013, 78, 4483-4489 (https://doi.org/10.1021/jo400487y).

Synthesis, antiviral evaluation and computational studies of cyclobutane and cyclobutene L-nucleoside analogues

Miralles-Llumà, R.; Figueras, A.; Busqué, F.; Alvarez-Larena, A.; Balzarini, J.; Figueredo, M.; Font, J.; Alibés, R.; Maréchal, J.-D.

Eur. J. Org. Chem. 2013, 4483-4489 (https://doi.org/10.1002/ejoc.201301097).

Encapsulation and Release Mechanisms in Coordination Polymer Nanoparticles

Amorín-Ferré, L.; Busqué, F.; Bourdelande, J.L.; Ruiz-Molina, D.; Hernando, J.; Novio, F.

Chem. Eur. J. 2013, 19, 17508-17516 (https://doi.org/10.1002/chem.201302662)

In quest of new drugs: the case of some antiretrovirals

Font, J.; Alibes, R.; Busquè, F.; Maréchal, J. D.

Revista de la Societat Catalana de Quimica 2013, 12, 35-41 (https://raco.cat/index.php/RevistaSCQ/article/view/276053)

Versatile nanostructured materials via direct reaction of functionalized catechols

Saiz-Poseu, J.; Sedó, J.; Garcia, B.; Benaiges, C.; Parella, T.; Alibés, R.; Hernando, J.; Busqué, F.; Ruiz-Molina. D.

Adv. Mater. 2013, 25, 2066-2070 (https://doi.org/10.1002/adma.201204383)

Catechol-based Biomimetic Functional Materials

Sedó, J.; Saiz-Poseu, J.; Busqué, F.; Ruiz-Molina. D.

Adv. Mater. 2013, 25, 653-701 (https://doi.org/10.1002/adma.201202343)

How a diversity-oriented approach has inspired a new hypothesis for the gabosine biosynthetic pathway. New synthesis of (+)-gabosine C

Fresneda, M. A.; Alibés, R.; Font, J; Bayón, P.; Figueredo, M.

Bioorg. Mol. Chem. 2013, 11, 6562-6568 (https://doi.org/10.1039/C3OB41183D)

Flexible approach to stemona alkaloids. total synthesis of (-)-stemospironine and three new diastereoisomeric analogs

Bardají, N.; Sánchez-Izquierdo, F.; Alibés, R.; Font, J.; Busqué, F.; Figueredo, M.

Org. Lett. 2012, 14, 4854-4857 (https://doi.org/10.1021/ol302185j).

Synthesis, anti-HIV activity studies, and in silico rationalization of cyclobutane-fused nucleosides

Figueras, A.; Miralles-Llumà, R.; Flores, R.; Rustullet, A.; Busqué, F.; Figueredo, M.; Font, J.; Alibés, R.; Maréchal, J.-D.

ChemMedChem 2012, 7, 1044-1056 (https://doi.org/10.1002/cmdc.201200059)

Stereoselective synthesis and relative configuration assignment of gabosine J

Fresneda, M. Angel; Alibés, R.; Font, J.; Bayón, P.; Figueredo, M.

J. Org. Chem. 2012, 77, 5030-5035 (https://doi.org/10.1021/jo300456q)

Switchable self-assembly of a bioinspired alkyl catechol at a solid/liquid interface: competitive interfacial, noncovalent, and solvent interactions

Saiz-Poseu, J.; Faraudo, J.; Figueras, A.; Alibés, R.; Busqué, F.; Ruiz-Molina, D.

Chem. Eur. J. 2012, 18, 3056-3063 (https://doi.org/10.1002/chem.201101940)

Synthetic studies of sesquiterpenes with dunniane skeleton

Parés, S.; Alibés, R.; Figueredo, M.; Font, J.; Parella, T.

Eur. J. Org. Chem. 2012, 1404-1417 (https://doi.org/10.1002/ejoc.201101614)

Self-assembly of alkylcatechols on HOPG investigated by scanning tunneling microscopy and molecular dynamics simulations

Saiz-Poseu, J.; Alcón, I.; Alibés, R.; Busqué, F.; Faraudo, J.; Ruiz-Molina, D.

CrystEngComm 1 2012, 14, 264-271 (https://doi.org/10.1039/C1CE06010D)

Divergent approach to gabosines and anhydrogabosines: enantioselective syntheses of (+)-Epiepoformin, (+)-Epoformin, (+)-Gabosine A, and Gabosines B and F

Toribio, G.; Marjanet, G.; Alibés, R.; de March, P.; Font, J.; Bayón, P.; Figueredo, M.

Eur. J. Org. Chem. 2011, 1534-1543 (https://doi.org/10.1002/ejoc.201001527)

Synthesis of purine nucleosides built on a 3-oxabicyclo[3.2.0]heptanes scaffold

Flores, R.; Rustullet, A.; Alibés, R.; Álvarez-Larena, A.; de March, P.; Figueredo, M.; Font; J.

J. Org. Chem. 2011, 76, 5369-5383 (https://doi.org/10.1021/jo200775x)

[2+2] Photocycloaddition of symmetrically disubstituted alkenes to 2(5H)-furanones. diastereoselective entry to 1,2,3,4-tetrasubstituted cyclobutanes

Parés, S.; de March, P.; Font, J.; Alibés, R.; Figueredo, M.

Eur. J. Org. Chem. 2011, 3888-3895 (https://doi.org/10.1002/ejoc.201100067)